Lung redox homeostasis: emerging concepts.

Targeting Redox Homeostasis in LKB1-Deficient NSCLC

Redox Homeostasis in Pancreatic β Cells

We reviewed mechanisms that determine reactive oxygen species (redox) homeostasis, redox information signaling and metabolic/regulatory function of autocrine insulin signaling in pancreatic β cells, and consequences of oxidative stress and dysregulation of redox/information signaling for their dysfunction. We emphasize the role of mitochondrion in β cell molecular physiology and pathology, incl...

Deciphering Molecular Cascades in a Novel Acclimatization Strategy for Rapid Ascent to High Altitude Altitude variation & rapid acclimation

The repercussions of hypobaric hypoxia are dependent upon two factorstime and intensity of exposure. The effects of intensity i.e. variation of altitude are yet unknown although it is a significant factor in terms of acclimatization protocols. In this study we present the effects of acute (24 h) exposure to high (10,000 ft), very high (15,000 ft) and extreme altitude (25,000 ft) zones on lung a...

Mechanosignaling in the vasculature: emerging concepts in sensing, transduction and physiological responses.

Cells are constantly exposed to mechanical forces that play a role in modulating cellular structure and function. The cardiovascular system experiences physical forces in the form of shear stress and stretch associated with blood flow and contraction, respectively. These forces are sensed by endothelial cells and cardiomyocytes and lead to responses that control vascular and cardiac homeostasis...

Decreased breath excretion of redox active iron in COPD: a protective failure?

Recent observational and genetic studies have highlighted a potential role for disrupted iron homeostasis in stable and exacerbating chronic obstructive pulmonary disease (COPD). Thus iron deficiency that is not limited to anaemia [1] and single nucleotide polymorphism in the gene encoding iron regulatory protein-2 [2], a key regulatory factor involved in cellular iron turnover and control, hav...